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KMID : 0383820110700030218
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Tuberculosis and Respiratory Diseases
2011 Volume.70 No. 3 p.218 ~ p.223
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Effects of Curcumin and Genistein on Phorbol Ester or Tumor Necrosis Factor-α-Induced Mucin Production from Human Airway Epithelial Cells
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Lee Su-Yel
Lee Hyun-Jae
Lee Jae-Woo
Jeon Byeong-Kyou
Kim Ju-Ock
Lee Choong-Jae
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Abstract
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Background: We investigated whether curcumin and genistein affect the MUC5AC mucin production from human airway epithelial cells that is induced by phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-α (TNF-α).
Methods: Confluent NCI-H292 cells were pretreated with each agent for 30 min and then stimulated with PMA or TNF-α for 24 hours. MUC5AC mucin production was measured by an ELISA.
Results: (1) Curcumin dose-dependently inhibited the production of MUC5AC mucin that was induced by PMA or TNF-α; (2) Genistein inhibited PMA-induced MUC5AC mucin production. However, it did not decrease TNF-α- induced MUC5AC mucin production.
Conclusion: These results suggest that curcumin and genistein inhibit the production of airway mucin induced by PMA.
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KEYWORD
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Mucin 5AC, Curcumin, Genistein
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